You are here

Murugappan Sathappa


Sathappa M, Alder NN. The ionization properties of cardiolipin and its variants in model bilayers. Biochim Biophys Acta Biomembranes. 2016;1858(6):1362-1372.

Baile MG, Sathappa M, Lu YW, et al. Unremodeled and remodeled cardiolipin are functionally indistinguishable in yeast. J Biol Chem. 2014;289:1768-1778.

Malhotra K, Sathappa M, Landin JS, Johnson AE, Alder NN. Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force. Nat Struct Mol Biol. 2013;20:965-972.

Murugappan Sathappa, Ph.D.

Murugappan Sathappa is a research scientist I in the protein science and structural biology group in the Center for the Development of Therapeutics (CDOT) of the Broad Institute of MIT and Harvard, where his major focus is the expression, purification, and biophysical/biochemical and structural characterization of challenging and novel protein targets. As an integral part of the structural biology team working to develop and design small molecule therapeutics, Sathappa is driving a new project utilizing his expertise in protein science and assay development for the identification of small molecule inhibitors for the treatment of hematological malignancies.

Prior to joining the Broad Institute in March 2017, Sathappa obtained his M.S. and Ph.D. in biochemistry from the University of Connecticut. During his Ph.D. work at the Alder Research Group, Sathappa utilized novel model membrane systems like membrane scaffolding proteins (MSP) and styrene maleic acid (SMA) copolymer-bound nanodiscs for studying mitochondrial membrane proteins in a native bilayer-like environment to gain insights into the physiology of the mitochondrial disorder Barth Syndrome. He was awarded the Richard C. Crain, Jr., Memorial Fellowship at the University of Connecticut in May 2016 in recognition of his demonstrated academic promise and research in the field of biochemistry.

Contact Murugappan Sathappa via email at


February 2018