You are here

Matthew Solomonson

Publications

Karczewski KJ, Francioli LC, Tiao G, et al. The mutational constraint spectrum quantified from variation in 141,456 humans [published correction appears in Nature. 2021 Feb;590(7846):E53] [published correction appears in Nature. 2021 Sep;597(7874):E3-E4]. Nature. 2020;581(7809):434-443. doi:10.1038/s41586-020-2308-7

Singh T, Poterba T, Curtis D, et al. Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature. 2022;604(7906):509-516. doi:10.1038/s41586-022-04556-w

COVID-19 Host Genetics Initiative.  Mapping the human genetic architecture of COVID-19. Nature. 2021;600(7889):472-477. doi:10.1038/s41586-021-03767-x

Karczewski, K.*, Solomonson, M.*, Chao, K. R.*, et al. Systematic single-variant and gene-based association testing of thousands of phenotypes in 426,370 UK Biobank exomes. Cell Genomics. 2022. In Press. doi.org/10.1101/2021.06.19.21259117

*co-first author

Matthew Solomonson, Ph.D.

Matthew Solomonson is the associate director of genomic data visualization in the Medical and Population Genetics Program (MPG) at the Broad Institute of MIT and Harvard. He is a member of the Translational Genomics Group (TGG) and the Analytic and Translational Genetics Unit (ATGU) at Massachusetts General Hospital. He is a protein structural biologist and software engineer. Solomonson is interested in developing customized web applications and software tools that enable researchers to explore large, complex biological datasets on the web.

Solomonson joined the Broad in 2016 to create the first iteration of the gnomAD browser, a resource for sharing variant data from hundreds of thousands of human exome and genome sequences. He is a member of the gnomAD leadership council, led by Mark Daly and Heidi Rehm. Solomonson also co-develops data-sharing resources for large-scale sequencing consortia in the Stanley Center for Psychiatric Research, including browsers for schizophrenia, epilepsy, bipolar disorder, and autism. In 2020, Solomonson led the development of the Covid-19 Host Genetics Initiative website for facilitating a global collaborative effort towards understanding the genetic factors underpinning Covid-19 susceptibility. Most recently, Solomonson developed Genebass, a web application for exploring exome-based association statistics across 4,529 phenotypes with gene-based and single-variant testing across 426,370 individuals with exome sequence data from the UK Biobank. Genebass was featured in the 2021 UK Biobank Scientific Conference.

Prior to joining the Broad, Solomonson completed his B.S. at the University of Alberta, Canada, and his Ph.D. in biochemistry and molecular biology at the University of British Columbia, Canada.

November 2022