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Mark Daly

Mark Daly, Ph.D.

Mark Daly is the founding chief of the Analytic and Translational Genetics Unit (ATGU) at Massachusetts General Hospital and an assistant professor at the Harvard Medical School. His research has historically focused on the development and application of statistical methods for the discovery and interpretation of genetic variation responsible for complex human disease. With the creation of the ATGU, he and other core faculty are focused on the interpretation of genome sequence and the use of genome information in clinical settings. Daly is also an institute member at the Broad Institute, where he leads many large scale genome sequencing studies in autism and inflammatory bowel disease.

While developing computational and statistical methods that can be broadly applied, his group has several primary medical genetics research foci. He has an extensive research program in neuropsychiatric genetics — particularly in autism, schizophrenia and ADHD — and has led large-scale GWAS and exome sequencing efforts in this area. His lab, along with Ben Neale's, serves as an analytic hub for the Psychiatric GWAS Consortium, an international consortium leading the largest collaborative GWAS studies in 5 major psychiatric disorders. He also has a longstanding effort in the mapping of genes for Crohn’s disease and ulcerative colitis, in which he helped found and lead an international effort that has identified more than 150 genetic risk factors. In collaboration with Ramnik Xavier’s group, this effort pursues the functional interpretation and clinical ramifications of these continued gene discovery efforts. Along with Heidi Rehm, he is co-PI of the gnomAD project and committed to ensuring the output of all ATGU genomic research is maximally accessible and useful to the clinical and research communities.

Daly was appointed director of the Institute of Molecular Medicine Finland (FIMM) at the University of Helsinki in February of 2018, and now divides his time between Helsinki and Boston, though he maintains his primary lab and affiliations in Boston. FIMM is a translational research institute with a focus on cancer, digital diagnostics, genetics, and epidemiology, and is the home of landmark efforts such as the FinnGen Project and the SUPER project which have active partnerships within the Broad.

Daly received his B.S. in physics from MIT and his Ph.D. in human genetics from Leiden University, Netherlands.

June 2021