Mario Suvà, M.D., Ph.D.
Mario Suvà is a physician-scientist in the department of pathology at Massachusetts General Hospital (MGH) and an institute member at the Broad Institute. Suvà’s expertise is in clinical neuropathology, single-cell sequencing technology, and cancer research.
Suvà's laboratory focuses on the biology of diffuse gliomas, in both adults and children. A particular effort of the laboratory is on dissecting the heterogeneity of patient tumors and relating transcriptional and genetic programs of individual cancer cells. Suvà co-directed landmark studies characterizing glioblastoma, oligodendroglioma, astrocytoma, and pediatric gliomas with single-cell genomic technologies, shedding light on tumor heterogeneity, tumor classification, glioma cell lineages, cancer stem cell programs, tumor evolution, and the composition of the tumor microenvironment.
Suvà earned his M.D. and Ph.D. from the University of Lausanne, Switzerland. His doctoral research identified cancer stem cells in Ewing sarcoma and highlighted mechanisms underlying their emergence. He conducted postdoctoral research at MGH and the Broad Institute with Brad Bernstein and David Louis, applying chromatin analysis and functional approaches to identify master regulators of glioma stem cell programs.