Malvina Papanastasiou

Malvina Papanastasiou, Ph.D.

Malvina Papanastasiou

Malvina Papanastasiou is a senior research scientist II in the Proteomics Platform at the Broad Institute of MIT and Harvard, where she works under the direction of Jacob Jaffe and Steven Carr. She is part of the LINCS Proteomic Characterization Center for Signaling and Epigenetics and part of her research uses mass spectrometry-based proteomics assays to profile cellular responses in the phosphosignaling and epigenetics space in response to drug or genetic perturbations. In addition, she works in developing hydrogen/deuterium exchange-mass spectrometry (HDX-MS) methods for studying protein dynamics, and protein-ligand and protein-protein interactions.

Prior to joining the Broad Institute in 2016, Papanastasiou accumulated experience in mass spectrometry-based proteomics and protein structure/function by HDX-MS. She undertook postdoctoral research at the Center for Drug Discovery at Northeastern University to develop MS-based approaches to characterize cannabinoid receptor-ligand interactions. She subsequently worked as a research scientist at the Institute of Molecular Biology and Biotechnology of the Foundation for Research and Technology - Hellas (FORTH), Heraklion, Greece, working on MS-based membrane proteomics. During this term, she also served as an EMBO visiting fellow at the University of Southern Denmark to study the structure of proteins involved in bacterial protein translocation by HDX-MS. She subsequently undertook a postdoctoral fellowship at the Perelman School of Medicine (UPenn) investigating protein structure and protein-ligand interactions of components of the human complement system.

Papanastasiou obtained a M.S. and Ph.D. in chemistry at Manchester Metropolitan University, as well as a B.Sc. in environmental sciences from the University of the Aegean.

Contact Malvina Papanastasiou via email at

March 2023