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Mahmoud Ghandi


CCLE Consortium, GDSC Consortium. Pharmacogenomic agreement between two cancer cell line data sets. Nature. 2015;528(7580):84–87. Ghandi M, Lee

D, Noori M, Beer MA. Enhanced regulatory sequence prediction using gapped k-mer features. PLoS Comput Biol. 2014;10(7):e1003711 Goetz EM, Ghandi M,

Treacy DJ, et al., ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors, Cancer research. 2014; 74 (23), 7079-7089

Mahmoud Ghandi, Ph.D.

Mahmoud Ghandi is a group leader in Levi Garraway's lab under the direction of Levi Garraway. He leads the Computational Biology group in the Cancer Cell Line Encyclopedia (CCLE) project — a public collection of cancer cell line data consisting of over 1000 cancer cell lines — as part of the Cancer Program at the Broad Institute of MIT and Harvard. His group uses high-throughput genomics integrated with large-scale small molecules, shRNA, and CRISPR screens to study the molecular mechanisms of cancer, find new vulnerabilities and therapeutic targets, and investigate the mechanisms of drug resistance. The group also develops and uses state-of-the-art computational methods for integrative analysis of next generation sequencing data as well as proteomic, metabolomic, microRNA, and epigenetic data to build predictive models for drug sensitivities and to advance our understanding of cancer biology.

Ghandi completed his Ph.D. in biomedical engineering at Johns Hopkins University prior to joining the Broad Institute in 2012. During his doctoral studies, he undertook two summer internships, one with NextBio in Cupertino, California, and the other with Bristol-Myers Squibb in Syracuse, New York. He also had work experience with the Advanced Communications Research Institute after completion of his B.Sc. in electrical engineering from the Sharif University of Technology in Iran.

Among his many awards and honors are the Broad Institute Excellence Award in Collaboration/Support of Science, the Hedayat Innovation Award for Software Development, silver medals at the Association for Computing Machinery (ACM) International Collegiate Programming Contest World Finals and the 11th International Olympiad in Informatics, and a gold medal at the 8th National Informatics Olympiad.

Contact Mahmoud Ghandi at

January 2017