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Kasia Handing

Publications

Handing KB, Niedzialkowska E, Shabalin I et al. Characterizing metal-binding sites in proteins with X-ray crystallography. Nat Protoc. 2018 May;13(5):1062-1090.

Handing KB, Shabalin IG, Kassaar O et al. Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins. Chem Sci. 2016 Nov 1;7(11):6635-6648.

Handing KB, Shabalin IG, Szlachta K et al. Crystal structure of equine serum albumin in complex with cetirizine reveals a novel drug binding site. Mol Immunol. 2016 Mar;71:143-151.

Kasia Handing, Ph.D.

Kasia Handing is a research scientist working in the Center for the Development of Therapeutics (CDoT) at the Broad Institute of MIT and Harvard under the supervision of Chris Lemke. Her expertise focuses around protein production, characterization, and protein structure determination. She supports drug discovery efforts within CDoT by employing X-ray crystallography to determine the mode of interaction between a target protein and a small molecule (the potential drug). A detailed understanding of the protein–ligand interactions is crucial for development of new therapeutics and plays a key role in rational drug design.

Handing joined the Broad Institute in March 2017 after leaving a position as product manager and structural biology application scientist at Formulatrix. She previously had a 4-year post as a visiting graduate researcher at the University of Virginia and spent a number of years as a student researcher at Adam Mickiewicz University in Poznan, Poland, Intelligent Pharma in Barcelona, Spain, and Åbo Akademi University in Turku, Finland.

Handing holds a B.S. and M.S. in bioinformatics from Adam Mickiewicz University and a Ph.D. in biophysics (X-ray crystallography) from the University of Virginia.

Contact Kasia Handing via email at khanding@broadinstitute.org.

February 2019