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Karen Perez de Arce


Perez de Arce K, Stagi M. Co-culture synaptogenic assay: a new look at fluorescence reporters and technological devices. Pages 13–27 in Poulopoulos A (Ed.), Synapse Development: Methods and Protocols. New York: Humana Press.

Perez de Arce K, Schrod N, Metzbower SWR, et al. Topographic mapping of the synaptic cleft into adhesive nanodomains. Neuron 2015;88:1165–1172.

Robbins EM, Krupp AJ, Perez de Arce K, et al. Regulation of synapse number and plasticity by SynCAM 1-mediated synaptic adhesion. Neuron 2010;68(5):894-906.

Karen Perez de Arce, Ph.D.

Karen Perez de Arce is a research scientist I in the Stanley Center for Psychiatric Research of the Broad Institute of MIT and Harvard, where she works under the direction of Jeffrey Cottrell conducting translational neurobiology research to identify biochemical signaling pathways of synaptic plasticity underlying psychiatric diseases. Her principal research focus is on assay development using cutting-edge screening technologies such as ultra-high-content and high-throughput imaging in combination with genetic engineering tools to generate cellular models of diseases.

Prior to joining the Broad Institute in August 2017, Perez de Arce was a postdoctoral associate in the lab of Thomas Biederer at Yale University and subsequently at Tufts University, where she later became a research associate in the Biederer Lab.

Perez de Arce holds a Ph.D. in cellular and molecular biology, a M.S. in biology, and a B.S./M.S. in biochemistry, all earned at the Pontificia Universidad Católica de Chile, Santiago, Chile.

Contact Karen Perez de Arce via email at


March 2018