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Juan Pablo

Publications

Pablo JL, Greka A. Charting a TRP to novel therapeutic destinations for kidney diseases. Trends Pharmacol Sci. 2019;40(12):911-918.

Sharma SH*, Pablo JL*, Montesinos MS, Greka A and Hopkins CR. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg Med Chem Lett. 2019;29(2):155-159.

Pablo JL, Pitt GS. FGF14 is a regulator of KCNQ channels. Proc Natl Acad Sci U S A. 2017;114(1):154-159.

Juan Pablo, Ph.D.

Juan “Juanchi” Pablo is a research scientist in the lab of institute member Anna Greka and the Stanley Center for Psychiatric Research of the Broad Institute of MIT and Harvard, where he works under the direction of Greka and Jen Pan on the study of ion channels, membrane proteins that regulate all aspects of cellular function. He is now working toward translating our knowledge of these channels into clinically relevant discoveries. This takes the form of three major avenues: 1) identifying modulators of channel function with therapeutic potential, 2) elucidating the mechanism of action of substances that could be affecting ion channels, and 3) testing possible disease-causing mutations in ion channel genes. 

Prior to joining the Broad Institute in 2017, Pablo completed postdoctoral research fellowships at Boston Children’s Hospital/Harvard Medical School and Howard Hughes Medical Institute.

Pablo obtained a Ph.D. in neurobiology along with a certificate in cell and molecular biology from Duke University. He also holds a bachelor’s degree in molecular biology and biotechnology from the University of the Philippines.

Contact Juan Pablo via email at jpablo@broadinstitute.org.

February 2020