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Joseph D. Growney

Publications

Cho YS, Levell JR, Liu G, et al. Discovery and evaluation of clinical candidate IDH305, a brain penetrant mutant IDH1 inhibitor. ACS Med Chem Lett. 2017;8(10):1116–1121.

Reddy A, Growney JD, Wilson NS, et al. Gene expression ratios lead to accurate and translatable predictors of DR5 agonism across multiple tumor lineages. PLoS One. 2015;10(9):e0138486.

Shultz MD, Cao X, Chen CH, et al. Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors. J Med Chem. 2011;54(13):4752–4772. Epub 2011 Jun 17.

Joseph D. Growney, Ph.D.

Joseph Growney is the director of translational pharmacology within the Center for the Development of Therapeutics (CDoT) at the Broad Institute of MIT and Harvard. His research unit consists of cell biology, cell pharmacology, in vivo pharmacology, and cellular screening groups that work together with the CDoT discovery sciences and medicinal chemistry teams to identify, validate, and characterize potential novel therapeutics across multiple therapeutic areas.

Before joining the Broad Institute in 2018, Growney was a senior investigator at Novartis Institutes for Biomedical Research in Cambridge. As a project team leader, he led cross functional teams for both antibody and low molecular weight modalities. During his tenure as an in vivo pharmacologist in both drug discovery and translational research settings, he contributed decision-enabling pharmacology to numerous project teams across the oncology portfolio. Leading a group within the oncology pharmacology department, Growney and his team drove the development of multiple new in vivo tumor model platforms to support both targeted therapy and immune oncology drug discovery approaches.

Growney received his Ph.D. in genetics at Harvard University. He subsequently studied hematology and mouse models of leukemogenesis as an American Cancer Society postdoctoral fellow at Boston Children's Hospital before beginning a career in drug discovery at Novartis. He also holds a master's degree in medical science from Harvard Medical School.

Contact Joseph Growney via email at jgrowney@broadinstitute.org.

February 2019