Josep Mercader, Ph.D.
Josep M Mercader is a research scientist at the Broad Institute of MIT and Harvard and a research fellow at Harvard Medical School and Massachusetts General Hospital. His research focuses on the discovery of genetic variation associated with type 2 diabetes and related traits, their functional characterization, and the translation of genetic findings to the clinic.
As a research scientist at the Broad Institute, he has played leadership roles in the analysis of large-scale genetic datasets for the discovery of novel T2D-related genetic variants, through genome-wide association studies and whole-exome association studies, with a focus on diverse populations. He has contributed to characterization of the molecular mechanisms behind several genetic associations by integrating genetic data from functional genomics datasets. His current research focuses on disentangling the molecular and physiological mechanisms leading to an increased genetic risk for T2D, either through specific large effect genetic variants or through studying individuals at the tails of polygenic scores.
During his Ph.D. training (Center for Genomic Regulation, Barcelona, Spain, 2008) and postdoctoral fellowship (Barcelona Supercomputing Center, Barcelona, Spain), he developed expertise in biology, statistical genetics, systems biology, and genomics, and contributed to the development of tools and methods for genetic discovery and dissecting biological pathways associated with complex diseases. During his postdoc he developed methods to re-analyze publicly available data, which led to discovery of several novel genetic variants for type 2 diabetes and other complex traits.