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Jose Florez

CONTACT

Lab website: 
http://florezlab.mgh.harvard.edu/
Area of Focus: 
Diabetes
E-mail: 
jcflorez@broadinstitute.org

Publications

Rusu V, Hoch E, et al. Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms. Cell. 2017; 170(1): 199-212.

Merino J, et al. Genetically driven hyperglycemia increases risk of coronary artery disease separately from type 2 diabetes. Diabetes Care. 2017; 40(11): 687-93.

Fuchsberger C, Flannick J, Teslovich TM, et al. The genetic architecture of type 2 diabetes. Nature. 2016; 536: 41-47. 

Walford GA, Colomo N, Todd JN, et al. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic resource for type 2 diabetes. PLoS ONE. 2015; 10: e0121553.

SIGMA Type 2 Diabetes Consortium, et al. Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA. 2014; 311(22): 2305-14.

Jose Florez, M.D., Ph.D.

Jose C. Florez is an endocrinologist at the Massachusetts General Hospital (MGH), an associate professor at Harvard Medical School, and an institute member at the Broad Institute of MIT and Harvard, where he co-directs the Metabolism Program.

Florez and his group have contributed to the performance and analysis of high-throughput genome-wide association and sequencing studies in type 2 diabetes and related traits, in the Diabetes Genetics Initiative (formed by the Broad Institute, Lund University, and Novartis), the Framingham Heart Study, and other international consortia such as MAGIC, GENIE, DIAGRAM, T2D-GENES, and SIGMA. He leads the genetic research efforts of the Diabetes Prevention Program, through which the effects of genetic variants on the development of diabetes can be examined prospectively, and their impact on specific behavioral and pharmacological preventive interventions can be assessed. He is the principal investigator of the Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH), and also conducts other pharmacogenetic studies at MGH.  He is an author on more than 125 original publications and more than 40 reviews and book chapters. 

In addition to his research and teaching duties, Florez is clinically active in the MGH Diabetes Center, the endocrine inpatient consult service, and the Down Syndrome Program. He serves on the editorial boards for Human Genetics and the Journal of Clinical Endocrinology and Metabolism, and has been on editorial boards for Diabetes and Diabetologia; he is also the editor-in-chief for Current Diabetes Reports. Florez is the recipient of the MGH Physician Scientist Development Award, a Doris Duke Charitable Foundation Clinical Scientist Development Award, the MGH Department of Medicine Stephen Krane Award, the MGH Research Scholars Award, and the 2010 Presidential Early Career Award for Scientists and Engineers, the highest honor bestowed by the United States government on science and engineering professionals in the early stages of their independent research careers.

Florez earned his Ph.D. at Northwestern University and his M.D. at Northwestern University Medical School.

November 2017