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Jonathan Livny

Publications

Schreiber IV HL, Conover MS, Chou WC, et al. Differential expression of conserved functions among genetically diverse Escherichia coli is key to uropathogenic phenotypes. Science Transl Med. 2016 (Accepted).

Shishkin A, Giannoukos G, Kucukural A, et al. Simultaneous generation of many RNA-Seq libraries in a single reaction.  Nat Methods. 2015;2(4):323–325.

Livny J, Zhao X, Mandlik A, et al. Comparative RNA-Seq based dissection of the regulatory networks and environmental stimuli underlying Vibrio parahaemolyticus gene expression during infection. Nucleic Acids Res. 2014;42(19):12212–12223.

Jonathan Livny, Ph.D.

Jonathan Livny is a senior research scientist in the Infectious Disease and Microbiome Program at the Broad Institute of MIT and Harvard. His research focuses on understanding how bacteria adapt to changes in their environment by altering the expression of their genes. To enable comparison of gene expression in diverse bacterial species in myriad sample types and growth conditions, much of his work is dedicated to developing more robust and high-throughput methods for generating bacterial cDNA libraries and mining bacterial RNA-Seq data for biologically relevant trends. Working closely with numerous groups both within and outside the Broad, Livny uses these methods to gain insights into the physiological responses of diverse pathogens to the host environment during infection, uncover inter-species differences in the expression of conserved functions that drive pathogenicity, and define signatures of transcriptional responses to antibiotic exposure that enable rapid diagnosis of antibiotic resistant strains.

Prior to joining the Broad Institute in 2009, Livny was engaged in a postdoctoral research fellowship that was initiated at Tufts University School of Medicine in Boston and subsequently moved to Brigham and Women's Hospital/Harvard Medical School.

Livny earned his Ph.D. in cell and molecular biology at the University of Michigan, Ann Arbor, and holds a B.S. in molecular biology from the University of Wisconsin, Madison.

Contact Jonathan Livny at livny@broadinstitute.org.

April 2017