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Jason McCoy

Publications

McCoy JG, Ren Z, Stanevich V et al. The structure of a sugar transporter of the glucose superfamily provides insight into the elevator mechanism of membrane transport. Structure. 2016;24(6):956-964.

Bai Y, McCoy JG, Levin EJ et al. X-ray structure of a mammalian stearoyl-CoA desaturase. Nature. 2015;524(7564):252-256.

McCoy JG, Rusinova R, Kim DM et al. A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics. J Biol Chem. 2014;289(14):9535-9546.

Jason McCoy, Ph.D.

Jason McCoy is a research scientist in MITRA, a research group under the direction of Scott Vafai at the Broad Institute of MIT and Harvard. MITRA is a part of the Broad Metabolism Program with the mission of discovering novel mitochondrial therapeutics. The focus of McCoy’s work is developing assays to identify small molecule modulators of target proteins involved in mitochondrial disease.

Prior to joining the Broad Institute in 2015, McCoy obtained his Ph.D. at the University of Wisconsin, Madison, where he studied structure-function relationships in enzymes through X-ray crystallography and activity assays. As a postdoc, he worked with Crina Nimigean at Weill Cornell Medical College and Ming Zhou at Baylor College of Medicine. His research focused on studying ion permeation, selectivity, and ligand gating in channels, as well as conformational dynamics of membrane transporters using a variety of biophysical methods. These included X-ray crystallography, electrophysiology with planar lipid bilayers, stopped-flow liposomal assays, and ITC using channels reconstituted into nanodiscs.

Contact Jason McCoy via email at jmccoy@broadinstitute.org.

May 2017