You are here

Jamie Moroco


Moroco JA, Alvarado JJ, Staudt RP, et al. Remodeling of HIV-1 Nef structure by Src-family kinase binding. J Mol Biol. 2017;430(3):310-321.

Moroco JA, Baumgartner MP, Rust HL, et al. A discovery strategy for selective inhibitors of c-Src in complex with the focal adhesion kinase SH3/SH2-binding region. Chem Biol Drug Des. 2015;86(2):144-155.

Moroco JA, Craigo JK, Iacob RE, et al. Differential sensitivity of Src-family kinases to activation by SH3 domain displacement. PLoS One. 2014;9;8;e105629.

Jamie Moroco, Ph.D.

Jamie Moroco works as a research scientist on the Biochemistry team within Discovery Sciences in the Center for the Development of Therapeutics (CDoT) at the Broad Institute of MIT and Harvard. She leverages her background in hydrogen-deuterium exchange mass spectrometry (HDX-MS) and enzymology to understand protein structure, dynamics, and function, especially in cases where little is known about the protein. She also works on a project in collaboration with Deb Hung’s lab to understand the function and inhibition of FadD32, a target for the treatment of tuberculosis.       

Moroco joined the Broad Institute in December 2018 after leaving Northeastern University, where she had taken a post as an associate research scientist following completion of her postdoctoral studies. During her undergraduate studies, she worked in the Breast Cancer Clinical Research program at Magee Women’s Hospital and did research on DNA repair proteins at the Hillman Cancer Center in Pittsburgh, Pennsylvania.

Moroco holds a Ph.D. from the University of Pittsburgh School of Medicine, where she studied the enzymatic regulation and inhibition of several Src family kinases. Her postdoc involved learning the technique of HDX-MS in the laboratory of John Engen at Northeastern University, where she applied the technique to several projects to understand protein structure and dynamics. She also holds a B.S. in biological sciences from Carnegie Mellon University.

Contact Jamie Moroco via email at

April 2021