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Heidi Rehm

Heidi Rehm, Ph.D.

Heidi Rehm, a human geneticist and clinical laboratory director, is an institute member of the Broad Institute working closely with the Program in Medical and Population Genetics and the Clinical Research Sequencing Platform. She is also associate professor of pathology and director of the Clinical Molecular Genetics training program at Harvard Medical School (HMS), and associate medical geneticist at Brigham and Women’s Hospital (BWH) and co-chair of the BWH Genomics Center.

In 2001, Rehm began building the Laboratory for Molecular Medicine (LMM) within the Harvard-Partners Center for Genetics and Genomics. Now a part of Partners Healthcare Personalized Medicine, the LMM focuses on the rapid translation of new genetic discoveries into clinical tests and brings novel technologies and software systems into clinical use to support the integration of genetics into medicine. The laboratory, which Rehm now directs, has been a leader in translational medicine, and offers exome and genome sequencing services for both clinical diagnostics and to support genomic medicine research projects.

Rehm is one of several principal investigators of a major NIH-funded effort called ClinGen (Clinical Genome Resource) to support broad sharing of genotype and phenotype data. She is also a co-investigator of the MedSeq Project, an NIH-funded Clinical Sequencing Exploratory Research grant to explore the "Integration of Whole Genome Sequencing into Clinical Medicine,” and a co-investigator of the BabySeq Project that will implement and evaluate the clinical use of rapid genome sequencing as an adjunct to newborn screening. 

Rehm is involved in defining standards for the use of next generation sequencing in clinical diagnostics and the interpretation of sequence variants through her committee roles at the American College of Medical Genetics and Genomics. She is also a member of the Clinical Work Group and leading flagship projects within the Global Alliance for Genomics and Health, and serves as a council member of the Human Genome Organization, Human Genome Variation Society, and Human Variome Project. Among Rehm's honors are the BWH Physician Recognition Award for Clinical Innovation and the Boston Business Journal's 40 Under 40 Award for Civic Leadership. She was also a member of teams that won the 2012 CLARITY Challenge run by Boston Children’s Hospital and the 2013 Bio-IT World Editors’ Prize for the GeneInsight software system.

Rehm received her B.A. degree in molecular biology and biochemistry from Middlebury College before earning her M.S. in biomedical science from Harvard Medical School and Ph.D. in genetics from Harvard University. She completed her post-doctoral training with David Corey in neurobiology and a fellowship in clinical molecular genetics at Harvard Medical School.