You are here

Guillaume Poncet-Montange


Palmer WS, Poncet-Montange G, Liu G et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016; 59(4); 1440-54.

Poncet-Montange G, Zhan Y, Bardenhagen JP et al. Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2. Biochem J. 2015;466(2):337–346.

Gelin M, Poncet-Montange G, Assairi L, et al. Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound. Structure. 2012;20(6):1107–1117.

Poncet-Montange G, St Martin SJ, Bogatova OV, et al. A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets. J Biol Chem. 2011 Aug 5;286(31);27718–27728.

Guillaume Poncet-Montange, Pharm.D., Ph.D.

Guillaume Poncet-Montange is a senior research scientist I in the Center for the Development of Therapeutics (CDoT) at the Broad Institute of MIT and Harvard, working in Chris Lemke’s group where he leads a project in collaboration with Calico and AbbVie. Poncet-Montange is a pharmaceutical scientist with a focus on early drug discovery, including structure-guided drug design, fragment-based drug design, and direct-binding assays. He has worked in numerous therapeutic areas including neurodegenerative diseases (prion proteins), oncology (epigenetics, nuclear receptors, immuno-oncology), and infectious diseases (bacterial and viral).

Prior to joining the Broad Institute in 2018, Poncet-Montange used his background in pharmaceutical research and structural biology to develop a consistent track record of collaborations and scientific discoveries at a start-up company, Orthogon Therapeutics, LLC, and at the MD Anderson Cancer Center Institute for Applied Cancer Science.

Poncet-Montange holds a Pharm.D. from Université Paul Sabatier Toulouse III and a Ph.D. in structural biology from the University of Montpellier 1. His postdoctoral research was undertaken first at the University of Montpellier 2 and subsequently at the University of California, San Francisco in the lab of Nobel Laureate Stanley Prusiner.

Contact Guillaume Poncet-Montange via email at

January 2020