Eric

Eric
Cambridge Rindge and Latin School
Cambridge, MA

Mentors: 
Diane Genereux and Lucas Moirera 
Vertebrate Genomics 
 

In his application, Eric shared that “the most appealing aspect of spending my summer at the Broad Institute is the opportunity to establish relationships with like-minded peers and insightful mentors.” During his time at the Broad, he was paired with the Karlsson lab in the Vertebrate Genomics group, where he forged lasting connections with both his peers and mentors. The lab's research centers on how cells respond to maintain essential functions in changing environments. Eric and his partner focused on investigating how alternative splicing is affected by temperature changes across different mammalian species. They analyzed RNA sequencing data from the cells of eight organisms, which were cultured at both normal and elevated temperatures, using the rMATS program to compare isoform abundance under these conditions. Their research identified six genes that were significantly alternatively spliced in response to temperature stress. Further analysis of these genes' molecular functions could reveal crucial pathways affected by temperature variations. As the program concluded, Eric reflected on his experience, sharing that “BSSP was not only instrumental in my growth as a researcher but also enhanced my interpersonal skills. This life-changing experience allowed me to meet brilliant students and knowledgeable mentors.”