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Emmanuel Buys


Thoonen R, Cauwels A, Decaluwe K, et al. Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice. Nat. Commun. 2015;6:8482.

Buys ES, Raher MJ, Kirby A, et al. Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice. J Clin Invest. 2012;122(6):2316–2325.

Buys ES, Ko YC, Alt C, et al. Soluble guanylate cyclase α1–deficient mice: a novel murine model for primary open angle glaucoma. PLoS One. 2013;8(3):e60156.

Emmanuel Buys, Ph.D.

Emmanuel “Manu” Buys is an associate member of the Broad Institute of MIT and Harvard and heads a research team at Massachusetts General Hospital, as well as holding the posts of associate professor of anesthesia and associate professor of ophthalmology at Harvard Medical School. The current focus of his team’s research is characterization of nitric oxide signaling in the Weddell seal using emerging genomic information. These studies have the potential to make important biomedical contributions by advancing the development of therapies for diseases such as acute respiratory distress syndrome (in newborns and adults), pneumonia, sepsis, inflammatory bowel disease, stroke, myocardial infarction, and cancer. A more comprehensive understanding of the pathways involved, particularly in an animal that possesses nature’s solutions to the challenge of balancing oxygen supply and demand, may significantly enhance the ability to deliver more effective, innovative therapies to these and other patients.

Buys was elected as a Fellow of the American Heart Association (FAHA) in 2015 and has memberships in the Association for Research in Vision and Ophthalmology, the Heart Failure Society of America, the International Society for Eye Research, the Massachusetts Society of Anesthesiologists, and the MGH Department of Anesthesia, Critical Care and Pain Medicine Research Council. Among his awards are the 2007 MGH Research Fellows Poster Celebration; 2007 American Heart Association Merit Award for Young Investigators; 2010 Poster of Excellence, 5th annual MGH ORCD Poster Celebration; 2011 Finalist AHA Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigator; 2012 Best Team Abstract for MGH Clinical Research Day; and 2012 Department of Anesthesia Poster award for MGH Clinical Research Day. He holds two patents in relation to discoveries from work on glaucoma, both filed in 2015.

Buys earned a B.S. in biology and M.S. and Ph.D. degrees in biotechnology from Ghent University; his postdoctoral research was completed at MGH. In addition to English, he is fluent in Dutch and has some proficiency in French and German. He has been affiliated with the Broad Institute since 2014.

Contact Manu Buys via email at

June 2016