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Christopher Lemke

Christopher Lemke, Ph.D.

Christopher Lemke is senior group leader of the Structural Biology group in the Center for the Development of Therapeutics (CDoT) at the Broad Institute of MIT and Harvard. He is in charge of the macromolecular X-ray crystallography and computational chemistry efforts of CDoT. His group enables and supports fragment-based screening and rational design of ligands for numerous discovery projects, which range from highly validated but so-called “undruggable” targets to exciting new targets identified through the Broad Institute’s genetics-based screening capabilities. His goal is the integration of structural biology, computational chemistry, and medicinal chemistry in the creation of innovative new treatments for human disease.

Before joining the Broad Institute in January 2014, Lemke worked for 10 years with Boehringer Ingelheim conducting structural studies of antiviral drug targets.

Lemke holds a B.Sc. in applied biochemistry and genetics from the University of Guelph (Canada) and he earned his Ph.D. from the University of Toronto in structural biology and biochemistry. His postdoctoral work was undertaken in the lab of Albert Berghuis at McGill University.

Contact Christopher Lemke at

August 2018