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Christina Cuomo

Publications

Sephton-Clark P, Tenor JL, Toffaletti DL, et al. Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome [published online ahead of print, 2022 Nov 10]. mBio. 2022;13(6):e0262622. 

Matzko ME, Sephton-Clark PCS, Young EL, et al. A novel rRNA hybridization-based approach to rapid, accurate Candida identification directly from blood culture. Med Mycol. 2022;60(9):myac065.

Chow NA, Muñoz JF, Gade L, et al. Tracing the Evolutionary History and Global Expansion of Candida auris Using Population Genomic Analyses. mBio 2020 Apr 28;11(2):e03364-19.

Muñoz JF, Gade L, Chow NA, et alGenomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species. Nature Commun. 2018 Dec 17; 9(1): 5346.

Desjardins CA, Giamberardino C, Sykes SM, et al. Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformansGenome Research. 2017 Jul;27(7):1207-1219.

Christina Cuomo, Ph.D.

Christina Cuomo is director of the Fungal Genomics Group and associate director in the Genomic Center for Infectious Diseases at the Broad Institute of MIT and Harvard, where she is also an institute scientist. Her group uses genomic methods to characterize the evolution of fungal pathogens. Studying species across the fungal kingdom, her work has led to major insights into the unique features of pathogenic species, how genomes evolve, variation with pathogen populations, antifungal drug resistance, and genes involved in host interaction. Her work is highly collaborative, engaging a global network of teams of computational biologists, experimental scientists, clinicians, and field researchers.

Cuomo led projects for the first representative genomes of critical fungal species, including animal pathogens, plant pathogens, and model systems. Her group’s current focus is genomic analysis of major human fungal pathogens, with the overarching goal of better understanding the genetic basis of pathogenicity and drug resistance. These studies include the application of genomic and transcriptomic approaches to study the emerging drug-resistant species Candida auris, the Cryptococcus species complex, and species of dimorphic fungi.

Cuomo received her A.B. in biology from Bryn Mawr College and Ph.D. in genetics from Harvard University. She joined the Whitehead Institute/MIT Center for Genome Research, now part of the Broad Institute, in 2002 and now works in the Broad’s Infectious Disease and Microbiome Program. She is a fellow in the CIFAR Fungal Kingdom Program and in the American Academy of Microbiology and serves as editor-in-chief at the ASM journal Microbiology Spectrum.

Contact Christina Cuomo via email at cuomo@broadinstitute.org.

January 2023