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Chad Nusbaum

Chad Nusbaum, Ph.D.

Chad Nusbaum is the director of the Broad Technology Labs (BTL) and an institute scientist at the Broad Institute of MIT and Harvard. BTL serves as a center of technical innovation in support of institute research goals.

Over the past 20 years, Nusbaum has overseen technology development in a wide range of areas related to DNA sequencing and genomics. Currently, the BTL has significant ongoing efforts in development and optimization of new sample preparations for genome, epigenome and transcriptome analysis (including single cell approaches), mutational analysis of genome functional elements, improved instrument operation and performance, overall process optimization and development of new analytical tools. Nusbaum’s work as co-director of the Broad’s former Genome Sequencing and Analysis Program (GSAP) included leading genome sequencing and analysis projects for a wide range of organisms, such as viruses, prokaryotes, eukaryotes and protists. Some of GSAP’s more notable projects under his leadership have included the genomes of Phytophthora infestans, the causal agent of the Irish potato famine, and the Schizosacharomyces clade of brewers’ yeasts.

Nusbaum joined Broad’s predecessor, the Whitehead Institute/MIT Center for Genome Research, as a research scientist in 1996, helping to create genome-wide maps for human and mouse. The following year, he participated in the pilot project for human genome sequencing that pioneered high-throughput, large-scale methods. As part of this effort, he was responsible for building and leading sequencing and technology development teams. From 2001 to 2003, as co-director of GSAP, Nusbaum co-led the institute’s work as a major contributing center in the Human Genome Project and was responsible for the completion of five human chromosomes.

Nusbaum received his undergraduate degree in biology from Columbia University and his Ph.D. in biology from MIT.

June 2017