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Career Profile: Guo Wei

Career Profile: Guo Wei

Guo Wei is a senior group leader and research scientist in the Broad's Cancer Program and co-leader of the MCL1 Therapeutics Project. He coordinates the research and development for the project within the Broad Institute and with outside partners. Guo pioneered research targeting pro-survival proteins in cancer at the Broad Institute, identifying MCL1 as a potential drug target and revealing a potential patient population that would benefit from MCL1 therapeutics. Together with the MCL1 team, Guo is working toward the goal to develop an MCL1 inhibitor that reaches clinical development and benefits cancer patients whose cancer cells rely on MCL1 for survival. Guo enjoys working at Broad because it "is always at the cutting edge of biomedicine. Some fancy ideas may be deemed impossible or impractical elsewhere, but they may become reality at Broad."

Before coming to the institute, Guo studied cell death as a postdoc with the late Dr. Stanley Korsmeyer at Dana Farber Cancer Institute. Guo decided to work with Korsmeyer because of his excellent research, but also because Korsmeyer was a cancer survivor. Guo wanted to "do something that really matters to patients, not just get publications," and he felt that Korsmeyer was able to focus on important things due to his personal experience with cancer. Guo never regretted his choice: he believes that cell death is a key to successful cancer therapy. He continued his postdoc training in the lab of Broad Cancer Program director Todd Golub, still focused on tackling the pro-survival machinery in cancer cells, but with a Broad blend.

When Guo isn't in the lab, he's cooking up new dishes in the kitchen. Some of his fancy ideas about food take his recipes in unexpected directions. One time, he loaded a pizza with so many toppings, the other guests at potluck dinner assumed it was a stir-fry and started scooping veggies off the top. Guo earned his Ph.D. from Ohio State; he was "very happy" when the Buckeyes won the 2015 College Football Playoff National Championship and hopes for more championships for the Buckeyes.