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Bryan MacDonald


Zhang X, MacDonald BT, Gao H, et al. Characterization of Tiki, a new family of WNT-specific metalloproteases. J Biol Chem. 2015 Dec 2. pii: jbc.M115.677807 [Epub ahead of print] PMID: 26631728

MacDonald BT, Hien A, Zhang X, et al. Disulfide bond requirements for active Wnt ligands. J Biol Chem. 2014;289(26):18122–11836.

MacDonald BT, He X. Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb Perspect Biol. 2012;4(12).

Bryan MacDonald, Ph.D.

Bryan MacDonald is a research scientist II in the Program in Medical and Population Genetics of the Broad Institute of MIT and Harvard under the direction of Sekar Kathiresan and Patrick Ellinor.

As a research scientist at the Broad Institute, MacDonald specializes in discovery research, target validation, and assay development, and currently is a project leader focused on characterizing a novel target with the goal of developing HTS assays for drug discovery. He joined the Broad Institute in March 2015 to apply his training and experience as a member of the Broad-Bayer Cardiovascular Disease Program a partnership between the Broad Institute and Bayer. The program utilizes genome-wide association studies (GWAS) and genomic sequencing to identify and characterize new cardiovascular drug targets for myocardial infarction and atrial fibrillation.

MacDonald received his B.S. in cell and molecular biology from Missouri State and Ph.D. in human genetics from the University of Michigan under the mentorship of Miriam Meisler. For his postdoctoral research, he joined the laboratory of Xi He at Boston Children’s Hospital/Harvard Medical School to study the molecular mechanisms of the Wnt signaling pathway.

Contact MacDonald via email at

January 2016