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Brenton Paolella


Paolella BR, Gibson WJ, Urbanski LM, et al. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife. 2017;6: pii: e23268.

Paolella BR, Stiles CD. Gliomas “dope up” for growth. Cancer Cell. 2016;29(6):778-780.

Havrda MC, Paolella BR, Ran C, et al. Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment. Cancer Res. 2014;74(6):1822-1832.

Brenton Paolella, Ph.D.

Brenton Paolella is a research scientist II in the Cancer Program of the Broad Institute of MIT and Harvard, where he works under the direction of Francisca Vazquez as a member of the Cancer Dependency Map project. His work centers on using novel genome-scale methods to identify new vulnerabilities in cancer. Recent technological advances have enabled the systematic identification of genes on which cancer cells rely for their survival. Working with a team of computational and biological scientists, Paolella is helping to identify new cancer therapeutic targets and credential them in the laboratory for potential clinical advancement.

Paolella received his Ph.D. from the Geisel School of Medicine at Dartmouth College and holds a B.S. in molecular, cellular, and developmental biology from the University of New Hampshire. He completed his postdoctoral training at Dana-Farber Cancer Institute and the Broad Institute, joining the latter as an affiliated postdoc in 2012 and beginning his current post in 2017. He is a recipient of numerous awards including an NIH F32 postdoctoral fellowship, an NIH Loan Repayment award, and a Friends for Life Neuroblastoma Endowed Fellowship, and he was named an Albert J. Ryan fellow.

Contact Brenton Paolella via email at

February 2018