Handsaker RE, Van Doren V, Berman JR, Genovese G, et al. Large multiallelic copy number variations in humans. Nat Genet. 2015 Mar;47(3):296–303.
Boettger LM, Handsaker RE, Zody MC, McCarroll SA. Structural haplotypes and recent evolution of the human 17q21.31 region. Nat Genet. 2012 Jul 1;44(8):881–885.
Handsaker RE, Korn JM, Nemesh J, McCarroll SA. Discovery and genotyping of genome structural polymorphism by sequencing on a population scale. Nat Genet. 2011 Mar;43(3):269–276.
Li, H, Handsaker B, Wysoker A, Fennel T, et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009 Aug 15;25(16):2078-9.
Bob Handsaker is a senior principal software engineer working under the direction of Steve McCarroll in the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard. He is the principal author of Genome STRiP, a suite of software analysis methods for the discovery and analysis of structural variation/copy number variation from sequencing data.
Handsaker’s research focuses on genome structural variation, large scale changes in a person’s DNA that rearrange genes or lead to an increase or decrease in the number of copies of a gene in different individuals. Handsaker develops new computational methods to accurately characterize and measure these complex variants, to understand their distribution and evolutionary history in the human population, and to elucidate their contributions to many diverse human diseases.
Prior to joining the Broad Institute, Handsaker worked as a software architect/developer and technology consultant. He has been affiliated with the Broad Institute and the Whitehead Institute Center for Genome Research since 2002, joining the Broad full time in 2010. He was awarded the Broad Institute’s Excellence Award in Science/Engineering in 2014.
Handsaker holds a bachelor's degree in computer science from MIT.