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Besnik Bajrami

Publications

Bajrami B, Kwak HJ, Loison F, Nombela AC, Mondal S, Sakai J, Silberstein L, Luo HR. G-CSF maintains controlled neutrophil mobilization during acute inflammation via negatively regulating CXCR2. J Exp Med 2016; 213 (10) :1999-2018.

Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT. A small molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat Chem Biol. 2017 Sep;13(9):943-950. doi: 10.1038/nchembio.2420. Epub 2017 Jul 3.

Bajrami B*, Kwak HJ*, Jia Y, Mondal S, Roy S, Silberstein L, Luo HR. Myeloid-derived reactive oxygen species externally regulate emergency granulopoiesis, 2015, Immunity;42(1):159-71.

Besnik Bajrami, Ph.D.

Besnik Bajrami works as a senior research scientist I in the Biochemistry group of the Discovery Sciences unit, within the Center for the Development of Therapeutics (CDoT) at the Broad Institute of MIT and Harvard under the direction of Virendar Kaushik. His role is to develop innovative mass spectrometry-based biochemical and biophysical assays to enable the study of compound affinity and potency along with compound-protein interactions and protein characterization in early therapeutic development projects.

Bajrami’s main areas of expertise include designing and implementing liquid chromatography-mass spectrometry (LCMS)-based bioanalytical and biochemical assays in early stage drug discovery projects to study enzyme kinetics; drug metabolism; ADME (absorption, distribution, metabolism, and excretion), and protein characterization. Prior to joining the Broad Institute in July 2015, Bajrami worked as a mass spectrometry applications chemist at Waters, developing innovative bioanalytical LCMS-based methodologies for DMPK (drug metabolism and pharmacokinetics) studies. This experience was preceded by a postdoctoral fellowship at Harvard Medical School/Boston Children’s Hospital studying the role of neutrophils and hematopoietic stem cells in innate immunity and during inflammation.

Bajrami obtained his Ph.D. in chemistry from the University of Connecticut, concentrated on studying CYP450 metabolism and genotoxicity, during which time he was awarded the university’s Doctoral Dissertation Fellowship Award. In addition to English, he is fluent in Albanian and has proficiency in Turkish, Croatian, and Macedonian languages.

Contact Besnik Bajrami via email at bbajrami@broadinstitute.org

August 2018