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Behnoush Hajian

Publications

Hajian B, Scocchera E, Shoen C, et al. Drugging the folate pathway in Mycobacterium tuberculosis: The role of multi-targeting agents. Cell Chem Biol. 2019;26(6):781-791  

Hajian B, Scocchera E, Keshipeddy S, et al. Propargyl-linked antifolates are potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis. PLoS One. 2016;11:8

Scocchera E, Reeve M, Keshipeddy S et al. Charged nonclassical antifolates with activity against gram-positive and gram-negative pathogens. ACS Med Chem Lett. 2016;7(7):692-696.  

Behnoush Hajian, Ph.D.

Behnoush Hajian is a research scientist in the Center for the Development of Therapeutics (CDoT) at the Broad Institute of MIT and Harvard under the direction of Christopher Lemke. She uses structural biology techniques, including X-ray crystallography, to determine three-dimensional structure of challenging macromolecular complexes and their mode of interactions with drug candidates. The goal of this structure-based drug design approach is to identify and optimize compounds that are suitable for clinical testing in the effort to develop new therapeutics for treating human diseases.

Hajian joined the Broad Institute in February 2019 after completing her Ph.D. in pharmaceutical sciences from the University of Connecticut (Anderson-Wright Group), where she worked on structure-based design of antifolates against antibiotic-resistant infectious diseases. She also holds a M.Sc. in biotechnology from Bu-Ali Sina University and a B.Sc. in plant pathology from Shiraz University.

Contact Behnoush Hajian via email at bhajian@broadinstitute.org.

January 2021