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Amedeo Vetere

Publications

Dirice E, Walpita D, Vetere A et al. Inhibition of DYRK1A stimulates human beta-cell proliferation. Diabetes 2016;65(6):1660–1671.

Chou DH-C, Vetere, A, Choudhary, A et al. Kinase-independent small-molecule inhibition of JAK-STAT signaling. J. Am. Chem. Soc., 2015; 137(24), 7929-7934.

Burns SM, Vetere A, Walpita D, et al. High-Throughput Luminescent Reporter of Insulin Secretion for Discovering Regulators of Pancreatic Beta-Cell Function. Cell Metabolism. 2015; 21, 126-137.

Amedeo Vetere, Ph.D.

Amedeo Vetere is a group leader in the Center for the Science of Therapeutics (CSofT) Chemical Biology Program at the Broad Institute of MIT and Harvard, where he works on the beta-cell biology and regenerative medicine project. His principal areas of expertise include beta-cell biology, chemical biology, probe discovery, assay development, and molecular biology. His research activity is focused towards small-molecule therapeutics for the treatment of type 1 diabetes, with a key goal of developing in vivo therapies that increase the number or function of pancreatic beta cells.

Prior to joining the Broad Institute in 2010, Vetere worked at the Joslin Diabetes Center. His time there began as a sabbatical that extended for a full year when he was awarded the EASD/ADA Transatlantic Fellowship in 2004. He stayed on at the Joslin as a visiting scientist for an additional six years, focusing his scientific interests towards the molecular mechanisms that control beta-cell proliferation.

Vetere graduated from the School of Biological Sciences at the University of Naples (Italy) “Federico II” in 1989. From there, he became a research associate at the Stazione Zoologica “A. Dohrn” in Naples, working on understanding the physiological role of D-aspartic acid. In 1993 he was awarded a Technology Training Grant from the Italian Ministry for University and Research that allowed him to acquire competencies in the field of biomaterials at the Department of Biochemistry, Biophysics, and Macromolecular Chemistry at the University of Trieste (Italy), which later led to his undertaking a doctoral program in biochemistry there. Vetere’s doctorate focused on specific biotechnological methods to obtain biologically relevant oligosaccharides. He later joined the University of Trieste’s faculty as an assistant professor of biochemistry in the School of Medicine, where he continued researching the development of novel biocompatible polymer-based tools for biomedical applications.

Contact Amedeo Vetere via email at avetere@broadinstitute.org.

December 2016