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Amanda Kedaigle


Velasco S, Kedaigle AJ, et al. Individual brain organoids reproducibly form cell diversity of the human cerebral cortexNature. 2019;570:523-527.

The HD iPSC Consortium: Kedaigle AJ, Gipson TA, Yildirim F, et al. Developmental alterations in Huntington’s disease neural cells and pharmacological rescue in cells and mice. Nat Neurosci. 2017;20(5):648–660.

Amanda Kedaigle, Ph.D.

Amanda Kedaigle is a computational scientist in the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, working under the direction of Joshua Levin and Paola Arlotta.

Kedaigle’s research uses single-cell data to study new models of developing brains. In particular, she uses transcriptomic and epigenomic data from brain organoids to gain insight into human development as well as psychiatric disorders such as autism.

Kedaigle joined the Broad Institute in July 2018 after obtaining her Ph.D. in computational and systems biology from MIT, where she worked in Ernest Fraenkel’s lab. During her doctoral studies, she held a translational research preceptorship from Massachusetts General Hospital and received a graduate education in medical sciences certification from the Institute for Medical Engineering and Science. Kedaigle also holds a B.A. in bioinformatics from Wellesley College.

Contact Amanda Kedaigle via email at

January 2020