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Alessandro Arduini

Publications

Yang L, Calay ES, Fan J, Arduini A, et al. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. Science. 2015;349(6247):500-506.

Arduini A, Serviddio G, Escobar J, et al. Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. Am J Physiol Gastrointest Liver Physiol. 2011;301(1):G119-G127.

Gomez-Cabrera MC, Domenech E, Romagnoli M, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 2008;87(1):142-149.

Alessandro Arduini, Ph.D

Alessandro Arduini is a research scientist in the Cardiovascular Disease Initiative (CVDi) at the Broad Institute of MIT and Harvard, where he works under the direction of Patrick Ellinor and Sekar Kathiresan. Within the initiative, he joined the Precision Cardiology Laboratory, with focus on deciphering the complexity of the cardiovascular system by dissecting and interpreting the transcriptional signature of several cell clusters. He is a believer that a more granular understanding of cell diversity in the healthy and disease state will drive novel approaches for the treatment of this disease.

Arduini’s research interests lie in the link between genes and the environment, specifically in the space of metabolic and inflammatory diseases. Throughout his career, he elucidated some mechanistic aspects of sensing and signal transduction that regulate adaptive and maladaptive responses. He did this work in disease-relevant cellular and animal models of obesity, non-alcoholic steatohepatitis, diabetes, obstructive jaundice, atherosclerosis, and exercise, and current research spins around understanding mechanisms of heart failure.

Arduini joined the Broad Institute in 2017 after a very productive period at Harvard, in the lab of James Mitchell, where he studied a novel connection between nutrients, endothelial cell metabolism, and angiogenesis, and the lab of Gokhan Hotamisligil, where he elucidated a non-canonical regulation of the immune sensor PKR. Arduini’s interests for metabolic alterations and metabolic reprogramming during cellular phenotypic alterations stem from his graduate work in the area of mitochondrial dysfunction and redox biology under the direction of Juan Sastre at the University of Valencia, Spain.

Contact Alessandro Arduini via email at aarduini@broadinstitute.org.

April 2019