Bacterial Proteins

In-depth analysis of Bacillus subtilis proteome identifies new ORFs and traces the evolutionary history of modified proteins.

Ravikumar V, Nalpas NC, Anselm V, et al. In-depth analysis of Bacillus subtilis proteome identifies new ORFs and traces the evolutionary history of modified proteins. Sci Rep. 2018;8(1):17246. doi:10.1038/s41598-018-35589-9DOI Google Scholar PubMed

CylA is a sequence-specific protease involved in toxin biosynthesis.

Tang W, Bobeica SC, Wang L, van der Donk WA. CylA is a sequence-specific protease involved in toxin biosynthesis. J Ind Microbiol Biotechnol. 2019;46(3-4):537-549. doi:10.1007/s10295-018-2110-9DOI Google Scholar PubMed

Genome-wide discovery of epistatic loci affecting antibiotic resistance in Neisseria gonorrhoeae using evolutionary couplings.

Schubert B, Maddamsetti R, Nyman J, Farhat MR, Marks DS. Genome-wide discovery of epistatic loci affecting antibiotic resistance in Neisseria gonorrhoeae using evolutionary couplings. Nat Microbiol. 2019;4(2):328-338. doi:10.1038/s41564-018-0309-1DOI Google Scholar PubMed

Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors.

Fang C, Lee KK, Nietupski R, et al. Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors. Bioorg Med Chem Lett. 2018;28(22):3529-3533. doi:10.1016/j.bmcl.2018.09.037DOI Google Scholar PubMed

Engineered CRISPR-Cas9 nuclease with expanded targeting space.

Nishimasu H, Shi X, Ishiguro S, et al. Engineered CRISPR-Cas9 nuclease with expanded targeting space. Science. 2018;361(6408):1259-1262. doi:10.1126/science.aas9129DOI Google Scholar PubMed

SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance.

Liu K, Kong L, Graham DB, Carey KL, Xavier RJ. SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance. Cell Rep. 2021;36(4):109434. doi:10.1016/j.celrep.2021.109434DOI Google Scholar PubMed

One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1.

Harmand TJ, Bousbaine D, Chan A, et al. One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. Bioconjug Chem. 2018;29(10):3245-3249. doi:10.1021/acs.bioconjchem.8b00563DOI Google Scholar PubMed

Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of as a Mechanism of Ethionamide Resistance.

de Welzen L, Eldholm V, Maharaj K, Manson AL, Earl AM, Pym AS. Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of as a Mechanism of Ethionamide Resistance. Antimicrob Agents Chemother. 2017;61(12). doi:10.1128/AAC.01461-17DOI Google Scholar PubMed

A role for bacterial urease in gut dysbiosis and Crohn's disease.

Ni J, Shen TCD, Chen EZ, et al. A role for bacterial urease in gut dysbiosis and Crohn’s disease. Sci Transl Med. 2017;9(416). doi:10.1126/scitranslmed.aah6888DOI Google Scholar PubMed

Genes Contributing to the Unique Biology and Intrinsic Antibiotic Resistance of Enterococcus faecalis.

Gilmore MS, Salamzade R, Selleck E, et al. Genes Contributing to the Unique Biology and Intrinsic Antibiotic Resistance of Enterococcus faecalis. mBio. 2020;11(6). doi:10.1128/mBio.02962-20DOI Google Scholar PubMed