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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Manning A, Highland HM, Gasser J, et al. A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. 2017;66(7):2019-2032. doi:10.2337/db16-1329DOIGoogle ScholarPubMed
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Genetic effects influencing risk for major depressive disorder in China and Europe.
Bigdeli TB, Ripke S, Peterson RE, et al. Genetic effects influencing risk for major depressive disorder in China and Europe. Transl Psychiatry. 2017;7(3):e1074. doi:10.1038/tp.2016.292DOIGoogle ScholarPubMed
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Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
Low SK, Takahashi A, Ebana Y, et al. Identification of six new genetic loci associated with atrial fibrillation in the Japanese population. Nat Genet. 2017;49(6):953-958. doi:10.1038/ng.3842DOIGoogle ScholarPubMed
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Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients.
Schumacher SE, Shim BY, Corso G, et al. Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients. PLoS One. 2017;12(4):e0176045. doi:10.1371/journal.pone.0176045DOIGoogle ScholarPubMed
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Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.
Aung T, Ozaki M, Lee MC, et al. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat Genet. 2017;49(7):993-1004. doi:10.1038/ng.3875DOIGoogle ScholarPubMed
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Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.
Li Z, Chen J, Yu H, et al. Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. Nat Genet. 2017;49(11):1576-1583. doi:10.1038/ng.3973DOIGoogle ScholarPubMed
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The promise of discovering population-specific disease-associated genes in South Asia.
Nakatsuka N, Moorjani P, Rai N, et al. The promise of discovering population-specific disease-associated genes in South Asia. Nat Genet. 2017;49(9):1403-1407. doi:10.1038/ng.3917DOIGoogle ScholarPubMed
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Time-averaged disease activity fits better joint destruction in rheumatoid arthritis.
Tsuji H, Yano K, Furu M, et al. Time-averaged disease activity fits better joint destruction in rheumatoid arthritis. Sci Rep. 2017;7(1):5856. doi:10.1038/s41598-017-05581-wDOIGoogle ScholarPubMed
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Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
Lu X, Peloso GM, Liu DJ, et al. Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet. 2017;49(12):1722-1730. doi:10.1038/ng.3978DOIGoogle ScholarPubMed
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Actionable gene-based classification toward precision medicine in gastric cancer.
Ichikawa H, Nagahashi M, Shimada Y, et al. Actionable gene-based classification toward precision medicine in gastric cancer. Genome Med. 2017;9(1):93. doi:10.1186/s13073-017-0484-3DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

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