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Massively parallel assessment of human variants with base editor screens.
Hanna RE, Hegde M, Fagre C, et al. Massively parallel assessment of human variants with base editor screens. Cell. 2021;184(4):1064-1080.e20. doi:10.1016/j.cell.2021.01.012PubMedDOIGoogle Scholar
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PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells.
Lebon D, Collet L, Djordjevic S, et al. PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells. Cancer medicine. 2024;13(2):e6984. doi:10.1002/cam4.6984PubMedDOIGoogle Scholar
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Characterization of Target Gene Regulation by the Two Epstein-Barr Virus Oncogene LMP1 Domains Essential for B-cell Transformation.
Mitra B, Beri NR, Guo R, Burton EM, Murray-Nerger LA, Gewurz BE. Characterization of Target Gene Regulation by the Two Epstein-Barr Virus Oncogene LMP1 Domains Essential for B-cell Transformation. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.04.10.536234PubMedDOIGoogle Scholar
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The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.
Liu S, Marneth AE, Alexe G, et al. The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy. Blood Adv. 2018;2(23):3428-3442. doi:10.1182/bloodadvances.2018016733PubMedDOIGoogle Scholar
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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.
Schauer NJ, Liu X, Magin RS, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep. 2020;10(1):5324. doi:10.1038/s41598-020-62076-xPubMedDOIGoogle Scholar
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Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.
Aulas A, Lyons SM, Fay MM, Anderson P, Ivanov P. Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability. Cell Death Dis. 2018;9(11):1129. doi:10.1038/s41419-018-1173-xPubMedDOIGoogle Scholar
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When Small Molecules Are Like Real Estate: It's All about Location, Location, Location.
DeRan M, Wagner BK. When Small Molecules Are Like Real Estate: It’s All about Location, Location, Location. Cell Chem Biol. 2018;25(10):1169-1170. doi:10.1016/j.chembiol.2018.10.004PubMedDOIGoogle Scholar
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Cells Lacking the Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.
Oser MG, Fonseca R, Chakraborty AA, et al. Cells Lacking the Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival. Cancer Discov. 2019;9(2):230-247. doi:10.1158/2159-8290.CD-18-0389PubMedDOIGoogle Scholar
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Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies.
Hacken ET, Valentin R, Regis FFD, et al. Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies. JCI Insight. 2018;3(19). doi:10.1172/jci.insight.121438PubMedDOIGoogle Scholar
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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.
Xu D, Jin T, Zhu H, et al. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. 2018;174(6):1477-1491.e19. doi:10.1016/j.cell.2018.07.041PubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

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