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X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes.
Topa H, Benoit-Pilven C, Tukiainen T, Pietilainen O. X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes. Genome biology. 2024;25(1):144. doi:10.1186/s13059-024-03286-8Google ScholarDOIPubMed
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X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes.
Topa H, Benoit-Pilven C, Tukiainen T, Pietilainen O. X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes. Genome biology. 2024;25(1):144. doi:10.1186/s13059-024-03286-8Google ScholarDOIPubMed
Read more
Landscape of X chromosome inactivation across human tissues.
Tukiainen T, Villani AC, Yen A, et al. Landscape of X chromosome inactivation across human tissues. Nature. 2017;550(7675):244-248. doi:10.1038/nature24265Google ScholarDOIPubMed
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A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus.
Barutcu R, Maass PG, Lewandowski JP, Weiner CL, Rinn JL. A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus. Nat Commun. 2018;9(1):1444. doi:10.1038/s41467-018-03614-0Google ScholarDOIPubMed
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Statistics for X-chromosome associations.
Özbek U, Lin HM, Lin Y, et al. Statistics for X-chromosome associations. Genet Epidemiol. 2018;42(6):539-550. doi:10.1002/gepi.22132Google ScholarDOIPubMed
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The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome.
Engreitz JM, Pandya-Jones A, McDonel P, et al. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. Science. 2013;341(6147):1237973. doi:10.1126/science.1237973Google ScholarDOIPubMed
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Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.
Hacisuleyman E, Goff LA, Trapnell C, et al. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Nat Struct Mol Biol. 2014;21(2):198-206. doi:10.1038/nsmb.2764Google ScholarDOIPubMed
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Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.
Tukiainen T, Pirinen M, Sarin AP, et al. Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation. PLoS Genet. 2014;10(2):e1004127. doi:10.1371/journal.pgen.1004127Google ScholarDOIPubMed
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The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3.
McHugh CA, Chen CK, Chow A, et al. The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. Nature. 2015;521(7551):232-6. doi:10.1038/nature14443Google ScholarDOIPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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