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Manipulating cell fate through reprogramming: approaches and applications.
Yagi M, Horng JE, Hochedlinger K. Manipulating cell fate through reprogramming: approaches and applications. Development (Cambridge, England). 2024;151(19). doi:10.1242/dev.203090PubMedGoogle ScholarDOI
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Polymerization of ZBTB transcription factors regulates chromatin occupancy.
Park PMC, Park J, Brown J, et al. Polymerization of ZBTB transcription factors regulates chromatin occupancy. Molecular cell. 2024;84(13):2511-2524.e8. doi:10.1016/j.molcel.2024.06.010PubMedGoogle ScholarDOI
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An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing.
Waterbury AL, Kwok HS, Lee C, et al. An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing. Molecular cell. 2024. doi:10.1016/j.molcel.2024.05.017PubMedGoogle ScholarDOI
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Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma.
Zarif TE, Semaan K, Eid M, et al. Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma. Cell reports. 2024;43(6):114350. doi:10.1016/j.celrep.2024.114350PubMedGoogle ScholarDOI
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DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Takahashi M, Chong HB, Zhang S, et al. DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024. doi:10.1016/j.cell.2024.03.027PubMedGoogle ScholarDOI
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Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.
Wittich H, Ardlie K, Taylor KD, et al. Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.01.006PubMedGoogle ScholarDOI
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Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging.
Braunger JM, Cammarata L V, Sornapudi TR, Uhler C, Shivashankar G V. Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging. Aging cell. 2023:e14056. doi:10.1111/acel.14056PubMedGoogle ScholarDOI
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Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development.
Nameki RA, Chang H, Yu P, et al. Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.04.11.536378PubMedGoogle ScholarDOI
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Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements.
Hu Y, Ma S, Kartha VK, et al. Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.28.533945PubMedGoogle ScholarDOI
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Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements.
Hu Y, Ma S, Kartha VK, et al. Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.28.533945PubMedGoogle ScholarDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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