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Research landmarks on the 60th anniversary of Epstein-Barr virus.
Zhong LY, Xie C, Le Zhang L, et al. Research landmarks on the 60th anniversary of Epstein-Barr virus. Science China. Life sciences. 2024. doi:10.1007/s11427-024-2766-0DOIGoogle ScholarPubMed
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Anamnestic humoral correlates of immunity across SARS-CoV-2 variants of concern.
McNamara RP, Maron JS, Boucau J, et al. Anamnestic humoral correlates of immunity across SARS-CoV-2 variants of concern. mBio. 2023:e0090223. doi:10.1128/mbio.00902-23DOIGoogle ScholarPubMed
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Joint single-cell measurements of nuclear proteins and RNA in vivo.
Chung H, Parkhurst CN, Magee EM, et al. Joint single-cell measurements of nuclear proteins and RNA in vivo. Nat Methods. 2021;18(10):1204-1212. doi:10.1038/s41592-021-01278-1DOIGoogle ScholarPubMed
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Loose ends: almost one in five human genes still have unresolved coding status.
Abascal F, Juan D, Jungreis I, et al. Loose ends: almost one in five human genes still have unresolved coding status. Nucleic Acids Res. 2018;46(14):7070-7084. doi:10.1093/nar/gky587DOIGoogle ScholarPubMed
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Dissecting FcγR Regulation through a Multivalent Binding Model.
Robinett RA, Guan N, Lux A, Biburger M, Nimmerjahn F, Meyer AS. Dissecting FcγR Regulation through a Multivalent Binding Model. Cell Syst. 2018;7(1):41-48.e5. doi:10.1016/j.cels.2018.05.018DOIGoogle ScholarPubMed
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A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia.
Chen X, Gustafsson S, Whitington T, et al. A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia. Hum Mol Genet. 2018;27(10):1809-1818. doi:10.1093/hmg/ddy094DOIGoogle ScholarPubMed
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Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, et al. Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies. Neuron. 2018;100(6):1322-1336.e7. doi:10.1016/j.neuron.2018.10.014DOIGoogle ScholarPubMed
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A role for histone deacetylase activity in HDAC1-mediated transcriptional repression.
Hassig CA, Tong JK, Fleischer TC, et al. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc Natl Acad Sci U S A. 1998;95(7):3519-24.Google ScholarPubMed
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Active genes are tri-methylated at K4 of histone H3.
Santos-Rosa H, Schneider R, Bannister AJ, et al. Active genes are tri-methylated at K4 of histone H3. Nature. 2002;419(6905):407-11. doi:10.1038/nature01080DOIGoogle ScholarPubMed
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Synthesis and characterization of a novel glycopolymer with protective activity toward human anti-alpha-Gal antibodies.
Vetere A, Donati I, Campa C, Semeraro S, Gamini A, Paoletti S. Synthesis and characterization of a novel glycopolymer with protective activity toward human anti-alpha-Gal antibodies. Glycobiology. 2002;12(4):283-90.Google ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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