1.
Chen C, Li X, Neumann CS, Lo MM-C, Schreiber SL. Convergent diversity-oriented synthesis of small-molecule hybrids. Angew Chem Int Ed Engl. 2005;44(15):2249-52. doi:10.1002/anie.200462798.
1.
Lo MM-C, Neumann CS, Nagayama S, Perlstein EO, Schreiber SL. A library of spirooxindoles based on a stereoselective three-component coupling reaction. J Am Chem Soc. 2004;126(49):16077-86. doi:10.1021/ja045089d.
1.
Pizzirani D, Roberti M, Grimaudo S, et al. Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells. J Med Chem. 2009;52(21):6936-40. doi:10.1021/jm900907s.
1.
Masse CE, Ng PY, Fukase Y, Sanchez-Roselló M, Shaw JT. Divergent structural complexity from a linear reaction sequence: synthesis of fused and spirobicyclic gamma-lactams from common synthetic precursors. J Comb Chem. 2006;8(3):293-6. doi:10.1021/cc050153o.
1.
Lowe JT, Lee MD, Akella LB, et al. Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries. J Org Chem. 2012;77(17):7187-211. doi:10.1021/jo300974j.
1.
Basarab GS, Kern GH, McNulty J, et al. Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases. Sci Rep. 2015;5:11827. doi:10.1038/srep11827.