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Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate.
Cheng Z, Mugler CF, Keskin A, et al. Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate. Mol Cell. 2019;73(1):36-47.e10. doi:10.1016/j.molcel.2018.10.032PubMedDOIGoogle Scholar
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Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection.
Butcher RA, Schreiber SL. Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection. Proc Natl Acad Sci U S A. 2004;101(21):7868-73. doi:10.1073/pnas.0402317101DOIGoogle ScholarPubMed
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Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen .
Sephton-Clark PCS, Muñoz JF, Ballou ER, Cuomo CA, Voelz K. Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen . mSphere. 2018;3(5). doi:10.1128/mSphere.00403-18DOIGoogle ScholarPubMed
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Nucleus-specific expression in the multinuclear mushroom-forming fungus reveals different nuclear regulatory programs.
Gehrmann T, Pelkmans JF, Ohm RA, et al. Nucleus-specific expression in the multinuclear mushroom-forming fungus reveals different nuclear regulatory programs. Proc Natl Acad Sci U S A. 2018;115(17):4429-4434. doi:10.1073/pnas.1721381115DOIGoogle ScholarPubMed
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Conserved secondary structures in Aspergillus.
McGuire AM, Galagan JE. Conserved secondary structures in Aspergillus. PLoS One. 2008;3(7):e2812. doi:10.1371/journal.pone.0002812DOIGoogle ScholarPubMed
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High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis.
Schwartz S, Agarwala SD, Mumbach MR, et al. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell. 2013;155(6):1409-21. doi:10.1016/j.cell.2013.10.047DOIGoogle ScholarPubMed
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Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo.
Rouskin S, Zubradt M, Washietl S, Kellis M, Weissman JS. Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo. Nature. 2014;505(7485):701-5. doi:10.1038/nature12894DOIGoogle ScholarPubMed
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Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.
Janbon G, Ormerod KL, Paulet D, et al. Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. PLoS Genet. 2014;10(4):e1004261. doi:10.1371/journal.pgen.1004261DOIGoogle ScholarPubMed
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Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes.
Desjardins CA, Sanscrainte ND, Goldberg JM, et al. Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes. Nat Commun. 2015;6:7121. doi:10.1038/ncomms8121DOIGoogle ScholarPubMed
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Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling.
Marty AJ, Wüthrich M, Carmen JC, et al. Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling. Fungal Genet Biol. 2013;56:1-8. doi:10.1016/j.fgb.2013.03.001DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

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