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Chemistry and biology of the immunophilins and their immunosuppressive ligands.
Schreiber SL. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science. 1991;251(4991):283-7.Google ScholarPubMed
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A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase.
Harding MW, Galat A, Uehling DE, Schreiber SL. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature. 1989;341(6244):758-60. doi:10.1038/341758a0Google ScholarPubMedDOI
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The effect of the immunosuppressant FK-506 on alternate pathways of T cell activation.
Bierer BE, Schreiber SL, Burakoff SJ. The effect of the immunosuppressant FK-506 on alternate pathways of T cell activation. Eur J Immunol. 1991;21(2):439-45. doi:10.1002/eji.1830210228PubMedGoogle ScholarDOI
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TREM2: Keeping Microglia Fit during Good Times and Bad.
Hong S, Stevens B. TREM2: Keeping Microglia Fit during Good Times and Bad. Cell Metab. 2017;26(4):590-591. doi:10.1016/j.cmet.2017.09.010Google ScholarPubMedDOI
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CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.
Lehrman EK, Wilton DK, Litvina EY, et al. CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development. Neuron. 2018;100(1):120-134.e6. doi:10.1016/j.neuron.2018.09.017Google ScholarPubMedDOI
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Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.
Sekiya M, Wang M, Fujisaki N, et al. Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models. Genome Med. 2018;10(1):26. doi:10.1186/s13073-018-0530-9PubMedGoogle ScholarDOI
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Meningioma transcription factors link cell lineage with systemic metabolic cues.
Du Z, Brewster R, Merrill PH, et al. Meningioma transcription factors link cell lineage with systemic metabolic cues. Neuro Oncol. 2018;20(10):1331-1343. doi:10.1093/neuonc/noy057PubMedGoogle ScholarDOI
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Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.
Ramos YFM, Metrustry S, Arden N, et al. Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance. J Med Genet. 2014;51(9):596-604. doi:10.1136/jmedgenet-2014-102478Google ScholarPubMedDOI
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A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology.
Replogle JM, Chan G, White CC, et al. A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Ann Neurol. 2015;77(3):469-77. doi:10.1002/ana.24337Google ScholarPubMedDOI
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The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.
Ramirez-Ortiz ZG, Prasad A, Griffith JW, et al. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nat Immunol. 2015;16(5):495-504. doi:10.1038/ni.3143PubMedGoogle ScholarDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

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