Reactive Oxygen Species | Broad Institute

Beta-Hydroxybutyrate Augments Oxaliplatin-Induced Cytotoxicity by Altering Energy Metabolism in Colorectal Cancer Organoids.

Sever T, Ellidokuz EB, Basbinar Y, Ellidokuz H, Yilmaz Ömer H, Calibasi-Kocal G. Beta-Hydroxybutyrate Augments Oxaliplatin-Induced Cytotoxicity by Altering Energy Metabolism in Colorectal Cancer Organoids. Cancers. 2023;15(24). doi:10.3390/cancers15245724PubMed DOI Google Scholar

Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.

Aulas A, Lyons SM, Fay MM, Anderson P, Ivanov P. Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability. Cell Death Dis. 2018;9(11):1129. doi:10.1038/s41419-018-1173-xPubMed DOI Google Scholar

Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj L, Ide T, Gurkar AU, et al. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2011;475(7355):231-4. doi:10.1038/nature10167Google Scholar PubMed DOI

Adaptation of the black yeast Wangiella dermatitidis to ionizing radiation: molecular and cellular mechanisms.

Robertson KL, Mostaghim A, Cuomo CA, et al. Adaptation of the black yeast Wangiella dermatitidis to ionizing radiation: molecular and cellular mechanisms. PLoS One. 2012;7(11):e48674. doi:10.1371/journal.pone.0048674Google Scholar PubMed DOI

The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.

Wang H, Nicolay BN, Chick JM, et al. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature. 2017;546(7658):426-430. doi:10.1038/nature22797PubMed DOI Google Scholar

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.

Early JO, Menon D, Wyse CA, et al. Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proc Natl Acad Sci U S A. 2018;115(36):E8460-E8468. doi:10.1073/pnas.1800431115PubMed DOI Google Scholar

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study.

Yang HS, Yu L, White CC, et al. Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study. Lancet Neurol. 2018;17(9):773-781. doi:10.1016/S1474-4422(18)30251-5PubMed DOI Google Scholar

Accumulation of succinate controls activation of adipose tissue thermogenesis.

Mills EL, Pierce KA, Jedrychowski MP, et al. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018;560(7716):102-106. doi:10.1038/s41586-018-0353-2PubMed DOI Google Scholar

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress.

Shaw AT, Winslow MM, Magendantz M, et al. Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress. Proc Natl Acad Sci U S A. 2011;108(21):8773-8. doi:10.1073/pnas.1105941108PubMed DOI Google Scholar

A CRISPR screen identifies a pathway required for paraquat-induced cell death.

Reczek CR, Birsoy K, Kong H, et al. A CRISPR screen identifies a pathway required for paraquat-induced cell death. Nat Chem Biol. 2017;13(12):1274-1279. doi:10.1038/nchembio.2499PubMed DOI Google Scholar