Rats | Broad Institute

The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways.

Tripathy A, Thakurela S, Sahu MK, et al. The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways. PLoS One. 2018;13(12):e0208194. doi:10.1371/journal.pone.0208194PubMed Google Scholar DOI

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity.

Vincent BM, Tardiff DF, Piotrowski JS, et al. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Rep. 2018;25(10):2742-2754.e31. doi:10.1016/j.celrep.2018.11.028PubMed Google Scholar DOI

A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling.

Wu CH, Tatavarty V, Beltran PMJ, et al. A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling. Elife. 2022;11. doi:10.7554/eLife.74277PubMed Google Scholar DOI

A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives.

Li Y, Wei L, Meinsohn MC, et al. A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives. Proc Natl Acad Sci U S A. 2022;119(15):e2122512119. doi:10.1073/pnas.2122512119PubMed Google Scholar DOI

Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis.

Crews CM, Lane WS, Schreiber SL. Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A. 1996;93(9):4316-9.PubMed Google Scholar

FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors.

Schroeder FA, Chonde DB, Riley MM, et al. FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neurosci Lett. 2013;550:119-24. doi:10.1016/j.neulet.2013.06.016PubMed Google Scholar DOI

2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors.

Hua Z, Huang X, Bregman H, et al. 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors. Bioorg Med Chem Lett. 2012;22(17):5392-5. doi:10.1016/j.bmcl.2012.07.046PubMed Google Scholar DOI

Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4.

Yu H, Schreiber SL. Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4. Biochemistry. 1995;34(28):9103-10.PubMed Google Scholar

Predator odor evokes sex-independent stress responses in male and female Wistar rats and reduces phosphorylation of cyclic-adenosine monophosphate response element binding protein in the male, but not the female hippocampus.

Homiack D, O’Cinneide E, Hajmurad S, et al. Predator odor evokes sex-independent stress responses in male and female Wistar rats and reduces phosphorylation of cyclic-adenosine monophosphate response element binding protein in the male, but not the female hippocampus. Hippocampus. 2017;27(9):1016-1029. doi:10.1002/hipo.22749PubMed Google Scholar DOI

Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.

Suen KM, Lin CC, Seiler C, et al. Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells. Int J Biochem Cell Biol. 2018;94:89-97. doi:10.1016/j.biocel.2017.11.014PubMed Google Scholar DOI