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A Bright and Fast Red Fluorescent Protein Voltage Indicator That Reports Neuronal Activity in Organotypic Brain Slices.
Abdelfattah AS, Farhi SL, Zhao Y, et al. A Bright and Fast Red Fluorescent Protein Voltage Indicator That Reports Neuronal Activity in Organotypic Brain Slices. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016;36(8):2458-72. doi:10.1523/JNEUROSCI.3484-15.2016Google ScholarPubMedDOI
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Phage-assisted evolution and protein engineering yield compact, efficient prime editors.
Doman JL, Pandey S, Neugebauer ME, et al. Phage-assisted evolution and protein engineering yield compact, efficient prime editors. Cell. 2023;186(18):3983-4002.e26. doi:10.1016/j.cell.2023.07.039PubMedGoogle ScholarDOI
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Engineered CRISPR-Cas9 nuclease with expanded targeting space.
Nishimasu H, Shi X, Ishiguro S, et al. Engineered CRISPR-Cas9 nuclease with expanded targeting space. Science. 2018;361(6408):1259-1262. doi:10.1126/science.aas9129Google ScholarPubMedDOI
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Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues.
Krishnan Y, Rees HA, Rossitto CP, et al. Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues. Biomaterials. 2018;183:218-233. doi:10.1016/j.biomaterials.2018.08.050Google ScholarPubMedDOI
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One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1.
Harmand TJ, Bousbaine D, Chan A, et al. One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. Bioconjug Chem. 2018;29(10):3245-3249. doi:10.1021/acs.bioconjchem.8b00563Google ScholarPubMedDOI
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Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling.
Myers SA, Wright J, Peckner R, Kalish BT, Zhang F, Carr SA. Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling. Nat Methods. 2018;15(6):437-439. doi:10.1038/s41592-018-0007-1PubMedGoogle ScholarDOI
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Targeted DNA methylation in human cells using engineered dCas9-methyltransferases.
Xiong T, Meister GE, Workman RE, et al. Targeted DNA methylation in human cells using engineered dCas9-methyltransferases. Sci Rep. 2017;7(1):6732. doi:10.1038/s41598-017-06757-0PubMedGoogle ScholarDOI
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Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.
Rajavelu A, Lungu C, Emperle M, et al. Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2. Nucleic Acids Res. 2018;46(17):9044-9056. doi:10.1093/nar/gky715Google ScholarPubMedDOI
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Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Botuyan MV, Cui G, Drané P, et al. Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat Struct Mol Biol. 2018;25(7):591-600. doi:10.1038/s41594-018-0083-zGoogle ScholarPubMedDOI
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A genetically encoded tool for manipulation of NADP/NADPH in living cells.
Cracan V, Titov DV, Shen H, Grabarek Z, Mootha VK. A genetically encoded tool for manipulation of NADP/NADPH in living cells. Nat Chem Biol. 2017;13(10):1088-1095. doi:10.1038/nchembio.2454Google ScholarPubMedDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

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