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Comparative landscape of genetic dependencies in human and chimpanzee stem cells.
She R, Fair T, Schaefer NK, et al. Comparative landscape of genetic dependencies in human and chimpanzee stem cells. Cell. 2023. doi:10.1016/j.cell.2023.05.043PubMedGoogle ScholarDOI
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Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons.
Pietiläinen O, Trehan A, Meyer D, et al. Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons. Cell reports. 2023;42(1):111988. doi:10.1016/j.celrep.2022.111988PubMedGoogle ScholarDOI
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Greater genetic diversity is needed in human pluripotent stem cell models.
Ghosh S, Nehme R, Barrett LE. Greater genetic diversity is needed in human pluripotent stem cell models. Nat Commun. 2022;13(1):7301. doi:10.1038/s41467-022-34940-zPubMedGoogle ScholarDOI
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Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells.
Semrau S, Goldmann JE, Soumillon M, Mikkelsen TS, Jaenisch R, van Oudenaarden A. Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells. Nat Commun. 2017;8(1):1096. doi:10.1038/s41467-017-01076-4PubMedGoogle ScholarDOI
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Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling.
Chandrasekaran S, Zhang J, Sun Z, et al. Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling. Cell Rep. 2017;21(10):2965-2977. doi:10.1016/j.celrep.2017.07.048PubMedGoogle ScholarDOI
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An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.
Ferrer CM, Alders M, Postma AV, et al. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality. Genes Dev. 2018;32(5-6):373-388. doi:10.1101/gad.307330.117PubMedGoogle ScholarDOI
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Chromatin analysis in human early development reveals epigenetic transition during ZGA.
Wu J, Xu J, Liu B, et al. Chromatin analysis in human early development reveals epigenetic transition during ZGA. Nature. 2018;557(7704):256-260. doi:10.1038/s41586-018-0080-8PubMedGoogle ScholarDOI
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Cell diversity and network dynamics in photosensitive human brain organoids.
Quadrato G, Nguyen T, Macosko EZ, et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545(7652):48-53. doi:10.1038/nature22047PubMedGoogle ScholarDOI
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Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.
Odorico J, Markmann J, Melton D, et al. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018;102(8):1223-1229. doi:10.1097/TP.0000000000002217PubMedGoogle ScholarDOI
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lincRNAs act in the circuitry controlling pluripotency and differentiation.
Guttman M, Donaghey J, Carey BW, et al. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature. 2011;477(7364):295-300. doi:10.1038/nature10398PubMedGoogle ScholarDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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