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Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites.
Lansink LIM, Skinner OP, Engel JA, et al. Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites. mBio. 2023:e0112923. doi:10.1128/mbio.01129-23Google ScholarPubMedDOI
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MalDA, Accelerating Malaria Drug Discovery.
Yang T, Ottilie S, Istvan ES, et al. MalDA, Accelerating Malaria Drug Discovery. Trends Parasitol. 2021;37(6):493-507. doi:10.1016/j.pt.2021.01.009Google ScholarPubMedDOI
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Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
Tye MA, Payne C, Johansson C, et al. Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance. Nat Commun. 2022;13(1):4976. doi:10.1038/s41467-022-32630-4Google ScholarPubMedDOI
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Hits, leads and drugs against malaria through diversity-oriented synthesis.
Dandapani S, Comer E, Duvall JR, Munoz B. Hits, leads and drugs against malaria through diversity-oriented synthesis. Future Med Chem. 2012;4(18):2279-94. doi:10.4155/fmc.12.178Google ScholarPubMedDOI
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High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations.
Ndiaye YD, Diedhiou CK, Bei AK, et al. High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations. Malar J. 2017;16(1):153. doi:10.1186/s12936-017-1811-2Google ScholarPubMedDOI
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Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance.
Bei AK, Niang M, Deme AB, et al. Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance. J Infect Dis. 2018;217(4):622-627. doi:10.1093/infdis/jix580Google ScholarPubMedDOI
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Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages.
Kato N, March S, Bhatia SN, Marti M. Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages. Methods Mol Biol. 2018;1787:41-52. doi:10.1007/978-1-4939-7847-2_3Google ScholarPubMedDOI
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gametocytes display homing and vascular transmigration in the host bone marrow.
De Niz M, Meibalan E, Mejia P, et al. gametocytes display homing and vascular transmigration in the host bone marrow. Sci Adv. 2018;4(5):eaat3775. doi:10.1126/sciadv.aat3775Google ScholarPubMedDOI
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Assisted assembly: how to improve a de novo genome assembly by using related species.
Gnerre S, Lander ES, Lindblad-Toh K, Jaffe DB. Assisted assembly: how to improve a de novo genome assembly by using related species. Genome Biol. 2009;10(8):R88. doi:10.1186/gb-2009-10-8-r88Google ScholarPubMedDOI
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A PIP Gets the plasmodium protein export pathway going.
H Y Jiang R, Marti M. A PIP Gets the plasmodium protein export pathway going. Cell Host Microbe. 2012;11(2):99-100. doi:10.1016/j.chom.2012.01.011Google ScholarPubMedDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

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