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Pharmacogenetic Influences Over Mavacamten Pharmacokinetics: Considerations for the Treatment of Individuals With Hypertrophic Cardiomyopathy.
McGurk KA, Bilgehan N, Ware JS. Pharmacogenetic Influences Over Mavacamten Pharmacokinetics: Considerations for the Treatment of Individuals With Hypertrophic Cardiomyopathy. Circulation. 2024;149(23):1786-1788. doi:10.1161/CIRCULATIONAHA.123.066916Google ScholarPubMedDOI
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Pharmacogenetic Influences Over Mavacamten Pharmacokinetics: Considerations for the Treatment of Individuals With Hypertrophic Cardiomyopathy.
McGurk KA, Bilgehan N, Ware JS. Pharmacogenetic Influences Over Mavacamten Pharmacokinetics: Considerations for the Treatment of Individuals With Hypertrophic Cardiomyopathy. Circulation. 2024;149(23):1786-1788. doi:10.1161/CIRCULATIONAHA.123.066916Google ScholarPubMedDOI
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Analysis of schizophrenia-associated genetic markers in the HLA region as risk factors for tardive dyskinesia.
Wang R, Lu JY, Herbert D, et al. Analysis of schizophrenia-associated genetic markers in the HLA region as risk factors for tardive dyskinesia. Human psychopharmacology. 2024:e2898. doi:10.1002/hup.2898PubMedGoogle ScholarDOI
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Analysis of schizophrenia-associated genetic markers in the HLA region as risk factors for tardive dyskinesia.
Wang R, Lu JY, Herbert D, et al. Analysis of schizophrenia-associated genetic markers in the HLA region as risk factors for tardive dyskinesia. Human psychopharmacology. 2024:e2898. doi:10.1002/hup.2898PubMedGoogle ScholarDOI
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Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines.
Rees MG, Seashore-Ludlow B, Clemons PA. Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines. Methods Mol Biol. 2019;1888:233-254. doi:10.1007/978-1-4939-8891-4_14PubMedGoogle ScholarDOI
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An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.
Bester AC, Lee JD, Chavez A, et al. An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Cell. 2018;173(3):649-664.e20. doi:10.1016/j.cell.2018.03.052Google ScholarPubMedDOI
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Genetic basis of individual differences in the response to small-molecule drugs in yeast.
Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L. Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat Genet. 2007;39(4):496-502. doi:10.1038/ng1991PubMedGoogle ScholarDOI
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The Value of FLG Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients.
Luukkonen TM, Kiiski V, Ahola M, et al. The Value of FLG Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients. Acta Derm Venereol. 2017;97(4):456-463. doi:10.2340/00015555-2578PubMedGoogle ScholarDOI
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The pharmacogenetics of metformin.
Florez JC. The pharmacogenetics of metformin. Diabetologia. 2017;60(9):1648-1655. doi:10.1007/s00125-017-4335-yGoogle ScholarPubMedDOI
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Humanity in a Dish: Population Genetics with iPSCs.
Warren CR, Cowan CA. Humanity in a Dish: Population Genetics with iPSCs. Trends Cell Biol. 2018;28(1):46-57. doi:10.1016/j.tcb.2017.09.006Google ScholarPubMedDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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