Pancreas | Broad Institute

OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.

Vetere A, Li WC, Paroni F, et al. OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas. Diabetologia. 2010;53(1):115-22. doi:10.1007/s00125-009-1567-5PubMed DOI Google Scholar

The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2.

Marsich E, Vetere A, Di Piazza M, Tell G, Paoletti S. The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2. Biochem J. 2003;376(Pt 3):707-15. doi:10.1042/BJ20031021Google Scholar PubMed DOI

Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes.

Cheng CW, Villani V, Buono R, et al. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell. 2017;168(5):775-788.e12. doi:10.1016/j.cell.2017.01.040Google Scholar PubMed DOI

Characterising -regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues.

Zhang M, Lykke-Andersen S, Zhu B, et al. Characterising -regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues. Gut. 2018;67(3):521-533. doi:10.1136/gutjnl-2016-313146PubMed DOI Google Scholar

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.

Odorico J, Markmann J, Melton D, et al. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018;102(8):1223-1229. doi:10.1097/TP.0000000000002217Google Scholar PubMed DOI

A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors.

Alvarez MJ, Subramaniam PS, Tang LH, et al. A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors. Nat Genet. 2018;50(7):979-989. doi:10.1038/s41588-018-0138-4Google Scholar PubMed DOI

Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth.

Nissim S, Sherwood RI, Wucherpfennig J, et al. Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth. Dev Cell. 2014;28(4):423-37. doi:10.1016/j.devcel.2014.01.006PubMed DOI Google Scholar

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.

Kim HJ, Barnitz A, Kreslavsky T, et al. Stable inhibitory activity of regulatory T cells requires the transcription factor Helios. Science. 2015;350(6258):334-9. doi:10.1126/science.aad0616PubMed DOI Google Scholar

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.

Kubicek S, Gilbert JC, Fomina-Yadlin D, et al. Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. Proc Natl Acad Sci U S A. 2012;109(14):5364-9. doi:10.1073/pnas.1201079109PubMed DOI Google Scholar

A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo.

Cronican JJ, Beier KT, Davis TN, et al. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol. 2011;18(7):833-8. doi:10.1016/j.chembiol.2011.07.003PubMed DOI Google Scholar