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The new era of quantitative cell imaging-challenges and opportunities.
Bagheri N, Carpenter AE, Lundberg E, Plant AL, Horwitz R. The new era of quantitative cell imaging-challenges and opportunities. Mol Cell. 2022;82(2):241-247. doi:10.1016/j.molcel.2021.12.024DOIGoogle ScholarPubMed
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Challenges and emerging directions in single-cell analysis.
Yuan GC, Cai L, Elowitz M, et al. Challenges and emerging directions in single-cell analysis. Genome Biol. 2017;18(1):84. doi:10.1186/s13059-017-1218-yDOIGoogle ScholarPubMed
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Systematic morphological profiling of human gene and allele function via Cell Painting.
Rohban MH, Singh S, Wu X, et al. Systematic morphological profiling of human gene and allele function via Cell Painting. Elife. 2017;6. doi:10.7554/eLife.24060DOIGoogle ScholarPubMed
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Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds.
Melillo B, Zoller J, Hua BK, et al. Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds. J Am Chem Soc. 2018;140(37):11784-11790. doi:10.1021/jacs.8b07319DOIGoogle ScholarPubMed
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Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging.
Tomov ML, O’Neil A, Abbasi HS, et al. Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging. Commun Biol. 2021;4(1):786. doi:10.1038/s42003-021-02276-xDOIGoogle ScholarPubMed
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High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development.
Sharma K, Choi SY, Zhang Y, et al. High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development. Cell Rep. 2013;5(5):1330-41. doi:10.1016/j.celrep.2013.11.008DOIGoogle ScholarPubMed
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Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness.
Wang JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, Perlis RH. Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness. Transl Psychiatry. 2014;4:e428. doi:10.1038/tp.2014.72DOIGoogle ScholarPubMed
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Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives.
Nelson SD, Wawer MJ, Schreiber SL. Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives. Org Lett. 2016;18(24):6280-6283. doi:10.1021/acs.orglett.6b03118DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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