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The single-cell transcriptome program of nodule development cellular lineages in Medicago truncatula.
Pereira WJ, Boyd J, Conde D, et al. The single-cell transcriptome program of nodule development cellular lineages in Medicago truncatula. Cell reports. 2024;43(2):113747. doi:10.1016/j.celrep.2024.113747Google ScholarPubMedDOI
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Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors.
Kuruvilla FG, Shamji AF, Schreiber SL. Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors. Proc Natl Acad Sci U S A. 2001;98(13):7283-8. doi:10.1073/pnas.121186898Google ScholarPubMedDOI
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Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins.
Shamji AF, Kuruvilla FG, Schreiber SL. Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Curr Biol. 2000;10(24):1574-81.PubMedGoogle Scholar
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Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins.
Hardwick JS, Kuruvilla FG, Tong JK, Shamji AF, Schreiber SL. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc Natl Acad Sci U S A. 1999;96(26):14866-70.PubMedGoogle Scholar
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Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein.
Rosen MK, Michnick SW, Karplus M, Schreiber SL. Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein. Biochemistry. 1991;30(19):4774-89.PubMedGoogle Scholar
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Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.
Yu Z, Surface LE, Park CY, et al. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Elife. 2018;7. doi:10.7554/eLife.36620PubMedDOIGoogle Scholar
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An adjustable gas-mixing device to increase feasibility of in vitro culture of Plasmodium falciparum parasites in the field.
Bei AK, Patel SD, Volkman SK, et al. An adjustable gas-mixing device to increase feasibility of in vitro culture of Plasmodium falciparum parasites in the field. PLoS One. 2014;9(3):e90928. doi:10.1371/journal.pone.0090928PubMedDOIGoogle Scholar
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Natural variation in non-coding regions underlying phenotypic diversity in budding yeast.
Salinas F, de Boer CG, Abarca V, et al. Natural variation in non-coding regions underlying phenotypic diversity in budding yeast. Sci Rep. 2016;6:21849. doi:10.1038/srep21849PubMedDOIGoogle Scholar
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Steady-state and dynamic gene expression programs in Saccharomyces cerevisiae in response to variation in environmental nitrogen.
Airoldi EM, Miller D, Athanasiadou R, et al. Steady-state and dynamic gene expression programs in Saccharomyces cerevisiae in response to variation in environmental nitrogen. Mol Biol Cell. 2016;27(8):1383-96. doi:10.1091/mbc.E14-05-1013PubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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