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Multiomic profiling reveals timing of menopause predicts prefrontal cortex aging and cognitive function.
Gunter-Rahman F, Adams CD, Raju RM, Zhang Y, Lee EA, Messerlian C. Multiomic profiling reveals timing of menopause predicts prefrontal cortex aging and cognitive function. Aging cell. 2024:e14395. doi:10.1111/acel.14395PubMedDOIGoogle Scholar
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"Monitoring inflammatory, immune system mediators, and mitochondrial changes related to brain metabolism during space flight".
Tocci D, Ducai T, Stoute CAB, et al. "Monitoring inflammatory, immune system mediators, and mitochondrial changes related to brain metabolism during space flight". Frontiers in immunology. 2024;15:1422864. doi:10.3389/fimmu.2024.1422864PubMedDOIGoogle Scholar
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Subcellular one carbon metabolism in cancer, aging and epigenetics.
Bernasocchi T, Mostoslavsky R. Subcellular one carbon metabolism in cancer, aging and epigenetics. Frontiers in epigenetics and epigenomics. 2024;2. doi:10.3389/freae.2024.1451971PubMedDOIGoogle Scholar
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Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming.
Holman CD, Sakers AP, Calhoun RP, et al. Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming. eLife. 2024;12. doi:10.7554/eLife.87756PubMedDOIGoogle Scholar
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Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells.
Dellorusso P V, Proven MA, Calero-Nieto FJ, et al. Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells. Cell stem cell. 2024. doi:10.1016/j.stem.2024.04.020PubMedDOIGoogle Scholar
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Clonal Hematopoiesis Among Patients With Asymptomatic Carotid Stenosis Compounds Risk of Cardiovascular Death.
Natarajan P, Bellomo TR. Clonal Hematopoiesis Among Patients With Asymptomatic Carotid Stenosis Compounds Risk of Cardiovascular Death. Journal of the American College of Cardiology. 2024;83(18):1728-1730. doi:10.1016/j.jacc.2024.03.389PubMedDOIGoogle Scholar
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Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS.
Gete Y, Koblan LW, Mao X, et al. Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS. Aging cell. 2021;20(7):e13388. doi:10.1111/acel.13388PubMedDOIGoogle Scholar
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Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.
Mitchell W, Goeminne LJE, Tyshkovskiy A, et al. Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation. eLife. 2024;12. doi:10.7554/eLife.90579Google ScholarPubMedDOI
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Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.
Ganz J, Luquette LJ, Bizzotto S, et al. Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes. Cell. 2024. doi:10.1016/j.cell.2024.02.025PubMedDOIGoogle Scholar
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Associations of brain morphology with cortical proteins of cognitive resilience.
Poole VN, Ridwan AR, Arfanakis K, et al. Associations of brain morphology with cortical proteins of cognitive resilience. Neurobiology of aging. 2024;137:1-7. doi:10.1016/j.neurobiolaging.2024.02.005Google ScholarPubMedDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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